Clinical Trials Offer Mesothelioma Patients Access to Leading Edge Treatment Options
Clinical trials for malignant mesothelioma are among the best options for mesothelioma patients seeking to find new, effective treatments for their disease. Clinical trials may be offered in hospitals, medical research institutions or medical centers, and are often led by mesothelioma experts from prominent research universities. The trials test not only new treatment options, but also a variety of other medical needs as varied as screening, prevention, diagnosis and even access to virtual online support groups.
Clinical trials provide researchers with valuable information that may help current and future patients battle the incurable disease, and they provide patients with access to treatments for the disease not yet available through their primary care physician. A clinical trial is a critical stage in the arduous cancer research process and is central to finding a cure for mesothelioma.
Mesothelioma is a highly aggressive cancer of the lining of the lungs, chest or abdomen that is highly resistant to many cancer treatments. According to ClinicalTrials.gov, there are nearly 50 studies for malignant mesothelioma being conducted worldwide. Trial sites are located throughout the world and today some of the clinical trials are being conducted in the United States, Israel, Italy, Belgium, Netherlands and Germany.
The Intercultural Cancer Council reports that less than 5% of the over ten million cancer patients in the United States participate in clinical trials. In the report, two primary reasons were reported for this lack of participation: a lack of awareness of clinical trials and a mistrust of the research being conducted.
In the U.S., clinical trials are run according to strict guidelines. A federally funded trial, according to the National Institutes of Health, has safeguards in place to protect the participants. Participants in federally funded clinical trials are educated by the trial researchers with the following information prior to agreeing to become a participant in a clinical trial:
- What will happen during a study including eligibility criteria, evaluations and all procedures to be performed;
- The possible risks, benefits, alternatives, and responsibilities of the clinical trial are explained thoroughly to patients before they agree to participate;
- That a clinical study is reviewed by an independent review board prior to the start to ensure that potential risks are clearly stated, and that investigators take sufficient and appropriate measures to address risks before the study proceeds;
- The study will be closely monitored once it is underway by an independent committee for safety and conformation to the study documents;
- That their privacy will be protected; and
- The study will be ethical and will follow international and federal “good clinical practices” guidelines.
Mesothelioma patients who are knowledgeable about the nature and risk associated with a clinical trial are better able to work with their primary physician to determine whether a clinical trial is appropriate for the treatment of the their disease.
Mesothelioma patients that participate in clinical trials not only help the medical community in general, but they can realize many benefits for their specific medical needs.
Mesothelioma Clinical Trials
The following clinical trials for mesothelioma are currently seeking participants. The studies are sorted by their relevance to malignant mesothelioma. For more information on these or other clinical trials in progress, click here.
- Tivantinib in Treating Patients With Previously Treated Metastatic or Recurrent Malignant Mesothelioma
Conditions: Epithelial Mesothelioma; Recurrent Malignant Mesothelioma; Sarcomatous Mesothelioma; Stage II Malignant Mesothelioma; Stage III Malignant Mesothelioma; Stage IV Malignant Mesothelioma
Interventions: Drug: tivantinib; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); National Cancer Institute (NCI)
Recruiting - verified May 2013 - Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma
Condition: Unresectable Pleural or Peritoneal Malignant Mesothelioma
Interventions: Drug: Tremelimumab; Drug: Placebo
Sponsors: MedImmune LLC; MedImmune LLC
Recruiting - verified May 2013 - Clinical and Histopathologic Characteristics of BAP1 Mutations
Conditions: Malignant Pleural Mesothelioma (MPM); Choroidal Nevus; Primary Uveal Melanoma (UM); Metastatic Uveal Melanoma (UM)
Intervention: Other: tumor specimens
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2013 - Validation of the MiCK Assay
Condition: Mesothelioma, Small Cell Lung Cancer, NSCLC
Intervention:
Sponsors: DiaTech Oncology; DiaTech Oncology
Recruiting - verified January 2013 - A Phase II Study of Single-agent DOVitinib in Advanced Malignant PlEural Mesothelioma Which Has Progressed Following Prior Platinum-Antifolate Chemotherapy
Conditions: Advanced Malignant Pleural Mesothelioma; MPM
Intervention: Drug: Dovitinib
Sponsors: Ontario Clinical Oncology Group (OCOG); Ontario Clinical Oncology Group (OCOG); Novartis Pharmaceuticals
Not yet recruiting - verified January 2013 - Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma
Condition: Lung Cancer
Intervention: Biological: GL-ONC1
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Genelux Corporation
Recruiting - verified April 2013 - CRS-207 Cancer Vaccine in Combination With Chemotherapy as Front-line Treatment for Malignant Pleural Mesothelioma
Condition: Malignant Pleural Mesothelioma
Intervention: Biological: Vaccine plus chemotherapy
Sponsors: Aduro BioTech, Inc.; Aduro BioTech, Inc.
Recruiting - verified April 2013 - A Study of LY3023414 in Participants With Advanced Cancer
Conditions: Advanced Cancer; Metastatic Cancer; Lymphoma; Metastatic Breast Cancer; Malignant Mesothelioma
Interventions: Drug: LY3023414; Drug: Midazolam; Drug: Letrozole
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified May 2013 - Intracavitary Cisplatin-Fibrin Localized Chemotherapy After Pleurectomy/Decortication for Malignant Pleural Mesothelioma
Condition: Malignant Pleural Mesothelioma
Intervention: Drug: cisplatin - fibrin
Sponsors: University of Zurich; University of Zurich
Recruiting - verified April 2013 - Safety and Efficacy of Oshadi D and Oshadi R for Malignant Mesothelioma Treatment
Condition: Mesothelioma
Intervention: Drug: Oshadi D and Oshadi R
Sponsors: Oshadi Drug Administration; Oshadi Drug Administration
Not yet recruiting - verified January 2013 - Mithramycin for Lung, Esophagus, and Other Chest Cancers
Conditions: Lung Cancer; Esophageal Cancer; Mesothelioma; Gastrointestinal Neoplasms; Breast Cancer
Intervention: Drug: Mithramycin
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified February 2013 - Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed
Conditions: Peritoneal Carcinomatosis; Pseudomyxoma Peritonei; Peritoneal Mesothelioma
Intervention:
Sponsors: Universitaire Ziekenhuizen Leuven; Universitaire Ziekenhuizen Leuven
Recruiting - verified March 2012 - Do Your Genes Put You at a Higher Risk of Developing Mesothelioma
Condition: Mesothelioma
Intervention:
Sponsors: Wake Forest University; Wake Forest University; University of Pennsylvania; Mayo Clinic; New York University School of Medicine; Johns Hopkins University; Mount Sinai School of Medicine; Memorial Sloan-Kettering Cancer Center; Mesothelioma Applied Research Foundation, Inc.
Recruiting - verified January 2013 - Treating Cancer With Anti-mesothelin Modified Lymphocytes
Conditions: Metastatic Cancer; Pancreatic Cancer; Mesothelioma
Interventions: Drug: Fludarabine; Drug: Cycolphosphamide; Biological: Aldesleukin
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified February 2013 - A Phase II Trial to Assess TroVax® Plus Chemotherapy in Patients With Malignant Pleural Mesothelioma
Conditions: Malignant; Pleural; Mesothelioma
Interventions: Biological: TroVax®; Drug: Pemetrexed; Drug: Cisplatin; Dietary Supplement: Vitamin B12; Dietary Supplement: Folic Acid; Drug: Dexamethasone
Sponsors: Wales Cancer Trials Unit; Wales Cancer Trials Unit; Velindre NHS Trust; June Hancock Mesothelioma Research Fund; Velindre Cancer Centre Stepping Stones Appeal
Recruiting - verified March 2013