Liang You, M.D., Ph.D.
- Contact Address
- 2340 Sutter Street S-341, Box 0128
University of California, San Francisco
San Francisco, CA, 941430128 - Contact Phone
- (415) 514-0555
- Contact E-Mail
- lyou@cc.ucsf.edu
- Professional Affiliations
- Helen Diller Family Comprehensive Cancer Center
Program: Thoracic Oncology - University of California - San Francisco Medical Center
Program: Thoracic Oncology Laboratory
- Helen Diller Family Comprehensive Cancer Center
- Expertise
- Human cancer genetics and epigenetics
- Wnt Signaling Pathway
- Akt Signaling Pathway
- Lung Cancer
- Mesothelioma
- Small molecules, antibodies and recombinant proteins
- Molecular analysis on matched normal/tumor tissues
- Education
- Jinzhou Medical College, Jinzhou, P.R.C., Medicine, M.D., 1982 - 1987
- Medical College of Ohio, Pathology, Ph.D., 1988 - 1994
- Appointments
- Adjunct Assistant Professor of Surgery,
- Biography
Dr. Liang You received his M.D. in 1987 from the Jinzhou Medical College in China and his Ph.D. in pathology from the Medical College of Ohio in 1994. He began work at UCSF in the thoracic oncology laboratory after work at the National Cancer Institute. At UCSF, Dr. You has made a significant impact on lung cancer and mesothelioma research. Most notably, he has been been instrumental in helping Dr. David Jablons mold a fledgling research effort into a thriving molecular genomics laboratory, an integral part of the Comprehensive Cancer Center and nationally recognized.
Dr. You has been a creative and dynamic force in the lab and his work has led to numerous discoveries. He helped demonstrate the relationship of p14ARF tumor suppressor deletions to the p53 pathway in mesothelioma and the effects of oncolytic viruses upon these tumors. He also discovered several novel mechanisms for the activation of upstream WNT pathways.
Dr. You has helped identify several novel biomarkers and therapeutic targets in lung cancer and mesothelioma. He and his colleagues demonstrated overexpression of Dishevelled-3 and silencing of SFRP-2, SOCS-3 and WIF-1 through promoter methylation. Dr. You and chemist Dr. Naoaki Fujii developed a small molecule Wnt pathway inhibitor, FJ9, that disrupts the interaction between the Frizzled receptor and Dishevelled, a Wnt signal transducer.
Dr. You is currently investigating the use of recombinant human WIF-1 protein as a cancer therapy and seeking out new therapeutic targets and novel interventions. In November 2007, Dr. You was presented with the David Jablons “Asclepios” Award by the Bonnie J. Addario Lung Cancer Foundation for his pioneering research.
