1. Skip to header
  2. Skip to main
  3. Skip to content
  4. Skip to sidebar
  5. Skip to footer
Biao He, Ph.D.

Biao He, Ph.D.

Contact Address
Campus Box 0128
University Of California, San Francisco
San Francisco, CA, 941150128
Contact Phone
(415) 502-0555
Contact E-Mail
bhe@cc.ucsf.edu
Professional Affiliations
  1. Helen Diller Family Comprehensive Cancer Center
    Program:  Thoracic Oncology

Expertise
  1. Epigenetics
  2. Stem cell biology, cancer stem cells
  3. Isolation of lung cancer stem cells
  4. Novel targeted therapies for lung & colon cancer, mesothelioma
  5. Small molecule inhibitors
  6. Wnt and Hedgehog signaling
  7. Microarrays and high throughput scanning
Education
  1. Tsinghua University, Beijing, China, Biochemistry, B.S., 1988 - 1993
  2. Tsinghua University, Beijing, China, Biochemistry, M.S., 1993 - 1995
  3. University of Virginia, Molecular Genetics, Ph.D., 1995 - 2001
Residencies
  1. Postdoctoral Researcher, Helen Diller Family Comprehensive Cancer Center, 2001 - 2002
  2. Assistant Research Molecular Biologist, Helen Diller Family Comprehensive Cancer Center, 2002 - 2004
Fellowships
  1. Hua Luogeng Memorial Fellowship, Tsinghua University, Beijing, China,  1995
  2. Barbara Isackson Endowed Research Fellow, University of California - San Francisco,  2004
Biography

Dr. Biao He is a molecular geneticist and senior scientist in the Thoracic Oncology Laboratory at the UCSF Helen Diller Family Comprehensive Cancer Center. Di. Dr. He graduated from the prestigious Tsinghua University in Beijing, China with a B.S. and M.S. in Biochemistry. He later received a Ph.D. from the University of Virginia in molecular genetics.Dr. He was recruited to the Thoracic Oncology Laboratory based on his extensive knowledge of the Wnt signaling pathway and RNA interference (RNAi). He started as a postdoctoral fellow and soon advanced to Assistant Research Molecular Biologist. In 2004, Dr. he joined the faculty as an Adjunct Assistant Professor in the Department of Surgery. Since joining the lab in 2001, Dr. He been the author of numerous peer-reviewed papers.

Dr. He’s current research is focused on the molecular mechanisms of non-small cell lung cancer and mesothelioma, and development of targeted therapies against these diseases.

Summary of Research

  • Molecular biology of non-small cell lung cancer and mesothelioma with emphasis on identification and validation of novel markers and potential therapeutic targets.
  • Isolation of lung cancer stems cells.<'li>
  • Development and characterization of therapeutic monoclonal antibodies for in vitro pharmacology and in vivo preclinical studies.
  • Role of epigenetic alterations in certain promoters in carcinogenesis and use of methylation as an early marker for detection of lung cancer and mesothelioma.
  • Screening for small molecule inhibitors of these pathways to identify potential leads for future targeted therapies.