Current Trials for Mesothelioma

The following clinical trials for mesothelioma are currently seeking participants as of April 2009. The studies are sorted by their relevance to malignant mesothelioma. For more information on these or other clinical trials in progress, click here.

Cisplatin, Pemetrexed, and Imatinib Mesylate in Malignant Mesothelioma

Condition: Mesothelioma

Interventions: Drug: Cisplatin; Drug: Imatinib Mesylate; Drug: Pemetrexed

Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma

Conditions: Malignant Mesothelioma; Metastatic Cancer

Interventions: Other: talc; Procedure: therapeutic thoracoscopic surgery; Procedure: therapeutic thoracoscopy; Procedure: therapeutic videothoracoscopy

Dasatinib in Resectable Malignant Pleural Mesothelioma

Condition: Malignant Pleural Mesothelioma

Intervention: Drug: Dasatinib

Immunotoxin Therapy, Pemetrexed, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed by Surgery

Condition: Malignant Mesothelioma

Interventions: Biological: SS1(dsFv)-PE38 immunotoxin; Drug: cisplatin; Drug: pemetrexed disodium; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: pharmacological study; Procedure: quality-of-life assessment

Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma

Condition: Malignant Pleural Mesothelioma

Interventions: Procedure: Extrapleural pneumonectomy (EPP), Pleurectomy/Decortication; Drug: cisplatin; Drug: gemcitabine; Drug: amifostine; Drug: sodium thiosulfate

Study of CBP501 + Pemetrexed + Cisplatin in Patients With Solid Tumors (Phase I) and Patients With Malignant Pleural Mesothelioma (Phase II)

Conditions: Malignant Pleural Mesothelioma; MPM; Solid Tumors

Interventions: Drug: pemetrexed, cisplatin and CBP501; Drug: pemetrexed and cisplatin

Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

Conditions: Lung Cancer; Mesothelioma

Intervention: Observational study

Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma

Condition: Malignant Mesothelioma

Interventions: Drug: dasatinib; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis

Tomotherapy Treatment for Mesothelioma

Condition: Mesothelioma

Intervention: Procedure: Tomotherapy

Bortezomib in Treating Patients With Malignant Pleural Mesothelioma

Condition: Malignant Mesothelioma

Interventions: Drug: bortezomib; Procedure: quality-of-life assessment

AZD2171 in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery

Condition: Malignant Mesothelioma

Interventions: Drug: cediranib maleate; Other: laboratory biomarker analysis

Bortezomib and Cisplatin as First-Line Therapy in Treating Patients With Malignant Mesothelioma

Condition: Malignant Mesothelioma

Interventions: Drug: bortezomib; Drug: cisplatin

Pemetrexed Disodium and Cisplatin Followed by Surgery With or Without Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma

Condition: Malignant Mesothelioma

Interventions: Drug: cisplatin; Drug: pemetrexed disodium; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy

Antineoplaston Therapy in Treating Patients With Advanced Mesothelioma

Condition: Malignant Mesothelioma

Interventions: Drug: antineoplaston A10; Drug: antineoplaston AS2-1

Dendritic Cell-Based Immunotherapy in Mesothelioma

Condition: Malignant Pleural Mesothelioma

Intervention: Biological: tumor lysate-loaded autologous dendritic cells

Sunitinib in Treating Patients With Advanced Malignant Pleural Mesothelioma

Condition: Malignant Mesothelioma

Intervention: Drug: sunitinib malate

Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery

Condition: Malignant Mesothelioma

Interventions: Drug: chemotherapy; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy

Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of the Chest That Cannot Be Removed by Surgery

Condition: Malignant Mesothelioma

Interventions: Dietary Supplement: vitamin B12; Drug: cisplatin; Drug: pemetrexed disodium; Genetic: gene expression analysis; Other: laboratory biomarker analysis; Other: pharmacological study

Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery

Condition: Malignant Mesothelioma

Intervention: Drug: everolimus

Study of Patients With Non-Small Cell Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, Mediastinal or Chest Wall Neoplasms, or Lung Metastases From Cancers of Non-Thoracic Origin

Conditions: Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer

Interventions: Genetic: DNA methylation analysis; Genetic: gene expression analysis; Procedure: bronchoscopy; Procedure: endoscopic biopsy; Procedure: needle biopsy

Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant Mesothelioma

Condition: Mesothelioma

Interventions: Drug: bevacizumab; Drug: cisplatin; Drug: pemetrexed

An Efficacy Study of Milataxel (TL139) Administered Orally for Malignant Mesothelioma

Condition: Mesothelioma

Intervention: Drug: Milataxel

Eloxatin® Plus Gemcitabine Chemotherapy for Mesothelioma

Condition: Mesothelioma

Intervention: Drug: Oxaliplatin/Gemcitabine

An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma

Condition: Mesothelioma

Interventions: Drug: Vinorelbine; Drug: Vandetanib

Suberoylanilide Hydroxamic Acid (SAHA) Versus Placebo in Advanced Malignant Pleural Mesothelioma

Conditions: Mesothelioma; Lung Cancer

Interventions: Drug: Comparator: Suberoylanilide Hydroxamic Acid (SAHA); Drug: Comparator: Placebo

Study of Carboplatin and Vinorelbine in Malignant Pleural Mesothelioma

Condition: Malignant Pleural Mesothelioma

Intervention: Drug: Carboplatin and Vinorelbine

Study Using Chemotherapy Followed by Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced But Unresectable Malignant Pleural Mesothelioma

Condition: Mesothelioma

Intervention: Other: Pemetrexed + Cisplatin and Intensity Modulated Radiation Therapy

Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma

Conditions: Carcinoma, Non-Small-Cell Lung; Mesothelioma

Intervention: Drug: LBH 589

Sorafenib in Previously Treated Malignant Mesothelioma

Condition: Mesothelioma

Intervention: Drug: Sorafenib

An Efficacy Study of MORAb-009 in Subjects With Pleural Mesothelioma

Condition: Malignant Pleural Mesothelioma

Intervention: Drug: MORAb-009 by IV on Days 1 and 8 every 21 days for 6 cycles.

Phase II Study of Bevacizumab, Pemetrexed and Carboplatin as First-Line Therapy in Malignant Pleural Mesothelioma

Condition: Mesothelioma

Intervention: Drug: Bevacizumab, Pemetrexed, Carboplatin

Trimodal Lung-Sparing Treatment of Pleural Mesothelioma

Condition: Pleural Mesothelioma

Interventions: Drug: Doxorubicin and cisplatin (intrapleural) + cisplatin and pemetrexed (systemic); Drug: Cisplatin and doxorubicin (intrapleural)

Decitabine and FR901228 in Treating Patients With Advanced Lung Cancer, Esophageal Cancer, Pleural Mesothelioma, or Lung Metastases

Conditions: Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer

Interventions: Drug: celecoxib; Drug: decitabine; Drug: romidepsin

Mesothelioma Avastin Plus Pemetrexed-Cisplatin Study

Condition: Mesothelioma

Interventions: Drug: Standard Chemotherapy (Pemetrexed and Cisplatin); Drug: Standard Chemotherapy (Pemetrexed and Cisplatin) + Bevacizumab

Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide

Conditions: Soft Tissue Sarcoma; Mesothelioma

Intervention: Drug: Azacitidine In Combination With Temozolomide

Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate

Conditions: Pleural Mesothelioma; Malignant Pleural Mesothelioma

Interventions: Drug: Cisplatin; Drug: Sodium Thiosulfate; Drug: ALIMTA

Carboplatin, Bevacizumab and Pemetrexed in the First-Line Treatment of Patients With MPM

Condition: Mesothelioma

Intervention: Drug: Carboplatin, Bevacizumab and Pemetrexed

Short Neoadjuvant Hemithoracic IMRT for MPM

Condition: Malignant Pleural Mesothelioma

Intervention: Other: Pre-op RT +/- chemotherapy

Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors

Conditions: Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Lung Cancer; Malignant Mesothelioma; Pancreatic Cancer; Prostate Cancer; Sarcoma

Interventions: Drug: cisplatin; Drug: pemetrexed disodium; Drug: sorafenib tosylate

FR901228 and Flavopiridol in Treating Patients With Advanced Lung, Esophageal, or Pleural Cancer

Conditions: Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer

Interventions: Drug: alvocidib; Drug: romidepsin

Optical Coherence Tomography of the Airway in Detecting Abnormal Cells in Patients Undergoing Surgery for Lung Cancer or Lung Disease

Conditions: Lung Cancer; Malignant Mesothelioma; Metastatic Cancer; Precancerous/Nonmalignant Condition

Interventions: Procedure: bronchoscopic and lung imaging studies; Procedure: diagnostic bronchoscopy; Procedure: histopathologic examination; Procedure: optical coherence tomography

Gene Therapy for Pleural Malignancies

Conditions: Pleural Mesothelioma; Metastatic Pleural Effusions

Intervention: Gene Transfer: BG00001 (adenoviral-mediated interferon-beta)

A Study To Find The Best Dose Of SU011248 When Given With Pemetrexed, Pemetrexed And Cisplatin Or Pemetrexed And Carboplatin In Patients With Advanced Solid Tumors

Conditions: Mesothelioma; Non-Small Cell Lung Cancer; Neoplasms

Intervention: Drug: Sunitinib, Pemetrexed, Cisplatin, Carboplatin

Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis

Conditions: Stomach Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis; Mesothelioma

Interventions: Procedure: cytoreductive surgery; Procedure: intraoperative peritoneal hyperthermic chemotherapy with cisplatin and mitomycin

Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain

Condition: Cancer

Interventions: Drug: fentanyl sublingual spray; Other: questionnaire administration

Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma

Conditions: Solid Tumor; Lymphoma

Intervention: Drug: belinostat

Electronic Tool to Record Cancer Symptoms in Patients With Advanced Cancer Receiving Palliative Care

Condition: Cancer

Interventions: Other: counseling intervention; Procedure: cognitive assessment; Procedure: fatigue assessment and management; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment

Phase I Study of OSI-930 and Erlotinib in Cancer Tumors

Condition: Advanced Solid Tumors

Intervention: Drug: OSI-930 and erlotinib

1-Methyl-d-Tryptophan in Treating Patients With Relapsed or Refractory Solid Tumors

Condition: Cancer

Interventions: Drug: 1-methyl-d-tryptophan; Other: flow cytometry; Other: fluorescence activated cell sorting; Other: high performance liquid chromatography; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study

An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation

Conditions: Ovarian Neoplasms; Colorectal Neoplasms; Melanoma; Small Cell Lung Cancer; Liposarcoma

Interventions: Radiation: Ionizing radiation (IR) therapy; Radiation: Ionizing radiation (IR)

Study of Pemetrexed and Bevacizumab in Patients With Head and Neck Cancer

Condition: Cancer

Interventions: Drug: Pemetrexed; Drug: Bevacizumab

Study of Pemetrexed for Second-Line Pancreas Cancer

Condition: Pancreas Cancer

Intervention: Drug: pemetrexed

Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer

Conditions: Peritoneal Neoplasms; Retroperitoneal Neoplasms; Gastrointestinal Neoplasms; Adenocarcinoma; Neuroblastoma; Ovarian Neoplasms; Sarcoma; Adrenocortical Carcinoma; Wilms Tumor; Rhabdomyosarcoma; Desmoplastic Small Round Cell Tumor

Interventions: Drug: CHPP of Cisplatin; Procedure: Abdominal Surge