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Wednesday, March 10, 2010
Results from a new study indicate that an RNA molecule found in cancerous tissue may be useful in predicting a mesothelioma patient’s chances for survival after surgery. The researchers reported in Cancer Research that the presence of even one specific microRNA has significant predictive value for determining the course that mesothelioma will take after surgery.
Mesothelioma, an unusual form of cancer caused by exposure to airborne asbestos fibers, often has a complex growth pattern making complete surgical removal a difficult task. The goal of the surgery is to achieve a macroscopically-complete resection, which refers to the removal of all visible tumor cells. This type of test will give doctors another tool to identify post-surgical treatment for patients including chemotherapy or radiation.
MicroRNAs play a key role in biological processes, such as development, cell proliferation and apoptosis (the process of cell death). Thus, altered microRNA is likely to contribute to cancer and other diseases. MicroRNAs have been used as prognostic markers for numerous forms of cancer and as biomarkers to pinpoint the tissue where cancer originated. But few studies have explored the role of microRNAs in malignant pleural mesothelioma.
“Mesothelioma is a terrible disease, and this specific microRNA may help doctors and clinicians give patients and their families a more accurate prognosis of the disease and how post-surgical patients will likely respond,” said attorney Joseph W. Belluck. “It’s an important step in understanding and combating this disease.”
Belluck, a partner in the law firm Belluck & Fox, said the research represented a potential breakthrough in helping guide treatment of mesothelioma patients.
The research was supported in part by philanthropic grants from the law firm of Belluck & Fox, LLP in New York and the Stephen Banner Lung Cancer Foundation.
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Labels: mesothelioma, Research News
posted by Nancy Meredith at 7:48 AM
